Learn about the policies, regulations, and guidance that protect animals used in research, training, and testing. The Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) applies to activities supported by any PHS agency. The PHS Policy incorporates the U.S. Government Principles, the Guide, and the AVMA Guidelines.
Public Law 99-158, November 20, 1985, "Animals in Research"
The Health Research Extension Act (HREA) of 1985 provides the legislative mandate for the PHS Policy.
The development of knowledge necessary for the improvement of the health and well-being of humans as well as other animals requires in vivo experimentation with a wide variety of animal species. Whenever U.S. Government agencies develop requirements for testing, research, or training procedures involving the use of vertebrate animals, the following principles shall be considered.Learn About the U.S. Government Principles
The International Guiding Principles for Biomedical Research Involving Animals has been the framework for the development of laws, policies, and guidelines for over 25 years. When the Guiding Principles were written in 1985, the profession of laboratory animal medicine and science was still establishing best practices and standards of care.Download the Guiding Principles