Notices

The information provided on this page includes final Guide Notices issued by OLAW. To view current Requests for Information (RFIs), click the "By Topic" tab at the top of the table. RFIs with closed comment periods are not included in this list.

Disclaimer: OLAW develops, monitors, and exercises compliance oversight relative to the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy). One of OLAW's primary functions is to advise awarding units and awardee institutions concerning the implementation of the PHS Policy. OLAW often provides this advice by responding to policy-related questions submitted by such units and institutions. The following Notices provide guidance that represents OLAW's current thinking on these topics. This guidance is based on OLAW's experience with the subject matter and draws on best practices followed by the biomedical community regarding the use of research animals. Unless specific statutory or regulatory requirements are cited, the Notices should be viewed as recommendations in that an institution may use an alternative approach if the approach satisfies the requirements of the PHS Policy.

OLAW welcomes comments on any of its policy guidance. Comments may be emailed to OLAW at: olaw@mail.nih.gov (please insert the title of the specific guidance document in the subject field). All relevant comments will be considered in OLAW decisions on timing and content of revisions to guidance documents, or development of new guidance documents. Comments generally will not result in direct responses from OLAW.

 

 
Notice NumberTitleDate
NOT-OD-24-076Guidance on Flexibilities for Conducting Semiannual Program Review
(This replaces rescinded Notice NOT-OD-23-129 with the same name.)
March 22, 2024
NOT-OD-24-075Guidance on Flexibilities for Conducting Semiannual Inspections of Animal Facilities
(This replaces rescinded Notice NOT-OD-21-164 with the same name and the associated clarification NOT-OD-22-048)
March 22, 2024
NOT-OD-24-008Reminder: Annual Reports to the Office of Laboratory Animal Welfare due December 1, 2023October 11, 2023
NOT-OD-23-004Reminder: Annual Reports to the Office of Laboratory Animal Welfare due December 1, 2022October 3, 2022
NOT-OD-22-207OLAW Waivers to Conduct Semiannual Facility Inspections due to COVID-19 Will Expire October 1, 2022September 12, 2022
NOT-OD-22-006Notice of Clarification of Offeror Responsibilities Regarding Contract to Protocol Congruence ReviewOctober 18, 2021
NOT-OD-22-005Notice of Clarification of Institutional Responsibilities Regarding NIH Grant to Protocol Congruence ReviewOctober 18, 2021
NOT-OD-21-130Notice to Encourage Using AAALAC International Program Description Sections to Complete Parts of the OLAW Domestic Animal Welfare AssuranceJune 4, 2021
NOT-OD-21-022Notice of Office of Laboratory Animal Welfare Statement on Oversight of NIH-owned ChimpanzeesNovember 5, 2020
NOT-OD-20-143Grant and Contract Submission Requirements Regarding the Updated AVMA Guidelines for the Euthanasia of Animals: 2020 EditionJuly 13, 2020
NOT-OD-20-132Public Comments on the Implementation of the Updated AVMA Guidelines for the Euthanasia of Animals: 2020 EditionJune 30, 2020
NOT-OD-20-109Notice of Update to the Reporting Period of the Annual Report to OLAWMay 21, 2020
NOT-OD-20-095Notice of Memorandum of Understanding Between NIH and NASA Concerning Laboratory Animal WelfareApril 16, 2020
NOT-OD-19-136Report on Reducing Administrative Burden for Researchers: Animal Care and Use in ResearchAugust 28, 2019
NOT-OD-19-069Report on Site Visits to the Veterans Affairs Medical Centers with Focus on Canine Care and Use in ResearchJanuary 31, 2019
NOT-OD-17-010Reports on Site Visits to the National Primate Research Centers and the Federally Supported Chimpanzee SanctuaryOctober 25, 2016
NOT-OD-16-125Notice of Change in Animal Welfare Assurance Numbering SystemAugust 2, 2016
NOT-OD-16-006Simplification of the Vertebrate Animals Section of NIH Grant Applications and Contract ProposalsOctober 13, 2015
NOT-OD-15-139Notice of Memorandum of Understanding Between NIH and NSF Concerning Laboratory Animal WelfareAugust 10, 2015
NOT-OD-15-109Guidance on Qualifications of IACUC Nonscientific and Nonaffiliated MembersJune 9, 2015
NOT-OD-15-079Notice of Update to the Public Health Service Policy on Humane Care and Use of Laboratory AnimalsMarch 17, 2015
NOT-OD-15-028Notice of Office of Laboratory Animal Welfare Policy on Shared Animal Welfare ConcernsDecember 1, 2014
NOT-OD-14-126Guidance on Significant Changes to Animal ActivitiesAugust 26, 2014
NOT-OD-14-099Notice of Change in Criteria for Renewal of Domestic Animal Welfare AssurancesMay 29, 2014
NOT-OD-13-096Implementation of the Revised International Guiding Principles for Biomedical Research Involving AnimalsAugust 2, 2013
NOT-OD-13-044Notice of Change to Electronic Submission of Final Noncompliance Reports to the Office of Laboratory Animal WelfareFebruary 21, 2013
NOT-OD-12-148Guidance on Departures from the Provisions of the Guide for the Care and Use of Laboratory AnimalsSeptember 10, 2012
NOT-OD-12-081Change in Criteria for Renewal of Animal Welfare Assurances for Foreign InstitutionsMarch 8, 2012
NOT-OD-12-020Adoption and Implementation of the Guide for the Care and Use of Laboratory Animals: Eighth EditionDecember 2, 2011
NOT-OD-12-021Update of Sample Interinstitutional AssuranceDecember 1, 2011
NOT-OD-11-053Guidance to Reduce Regulatory Burden for IACUC Administration Regarding Alternate Members and Approval DatesMarch 18, 2011
NOT-OD-10-128Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal ResearchSeptember 1, 2010
NOT-OD-10-121Report on Site Visits to Chimpanzee Facilities and Associated Resources to Aid Grantee InstitutionsAugust 6, 2010
NOT-OD-10-114Update on Applicability of the Shelf Life Extension Program (SLEP)July 14, 2010
NOT-OD-10-102Update of the Guide for the Care and Use of Laboratory AnimalsJune 4, 2010
NOT-OD-10-049Instructions for Completion and Technical Evaluation of the Vertebrate Animal Section (VAS) in NIH Contract ProposalsApril 19, 2010
NOT-OD-10-083Update of Sample Animal Welfare Assurance for Foreign InstitutionsApril 16, 2010
NOT-OD-10-081Guidance on Confirming Appropriate Charges to NIH Awards during Periods of Noncompliance for Activities Involving AnimalsApril 15, 2010
NOT-OD-10-027Instructions for Completion and Peer Review of the Vertebrate Animal Section (VAS) in NIH Grant Applications and Cooperative AgreementsMarch 17, 2010
NOT-OD-09-035Guidance to IACUCs Regarding Use of Designated Member Review (DMR) for Animal Study Proposal Review Subsequent to Full Committee Review (FCR)January 8, 2009
NOT-OD-08-049Update of Sample Animal Welfare AssuranceFebruary 15, 2008
NOT-OD-07-044NIH Policy on Allowable Costs for Grant Activities Involving Animals when Terms and Conditions are not UpheldJanuary 26, 2007
NOT-OD-06-052Guidance on Use of Telecommunications for IACUC MeetingsMarch 24, 2006
NOT-OD-05-034Guidance on Prompt Reporting to OLAW under the PHS Policy on Humane Care and Use of Laboratory AnimalsFebruary 24, 2005
NOT-OD-04-052Office of Extramural Research Notice Regarding Animal Welfare Documents Submitted to the Office of Laboratory Animal Welfare July 13, 2004
NOT-OD-03-046Revised Guidance Regarding IACUC Approval of Changes in Personnel Involved in Animal ActivitiesJune 6, 2003
NOT-OD-01-017Guidance Regarding Administrative IACUC Issues (alternate IACUC members, IACUC review at collaborating institutions) and Efforts to Reduce Regulatory BurdenFebruary 12, 2001
NOT-OD-00-019Guidance Concerning the Production of Monoclonal Antibodies in AnimalsFebruary 3, 2000
NOT-OD-00-007Guidance Regarding Reduction of Regulatory BurdenDecember 21, 1999
NOT-OD-98-01Production of Monoclonal Antibodies Using Mouse Ascites MethodNovember 17, 1997
OPRR REPORTS 97-03Maintenance of Properly Constituted IACUCsJune 2, 1997
OPRR REPORTS 97-02NASA Principles for the Ethical Care and Use of AnimalsMay 30, 1997
OPRR REPORTS 95-03Sources of Custom Antibody ProductionMarch 8, 1995
OPRR REPORTS 94-01Internal Distribution of Your Animal Welfare AssuranceJanuary 11, 1994
OPRR REPORTS 90-01Use of Expedited Protocol Review Procedures by IACUCsMay 21, 1990
 

  Current Requests for Information (RFIs)

 

12/22/2023 ---No current RFIs---Expiration Date

   Administrative

  NOT-OD-16-125Notice of Change in Animal Welfare Assurance Numbering SystemAugust 2, 2016
  NOT-OD-10-114Update on Applicability of the Shelf Life Extension Program (SLEP)July 14, 2010

   Animal Use and Management

  NOT-OD-00-019Guidance Concerning the Production of Monoclonal Antibodies in AnimalsFebruary 3, 2000
  OPRR Reports 98-01Production of Monoclonal Antibodies Using Mouse Ascites MethodNovember 17, 1997
  OPRR Reports 95-03Sources of Custom Antibody ProductionMarch 8, 1995

   Animal Welfare Assurances

  NOT-OD-21-130Notice to Encourage Using AAALAC International Program Description Sections to Complete Parts of the OLAW Domestic Animal Welfare AssuranceJune 4, 2021
  NOT-OD-14-099Notice of Change in Criteria for Renewal of Domestic Animal Welfare AssurancesMay 29, 2014
  NOT-OD-12-081Change in Criteria for Renewal of Animal Welfare Assurances for Foreign InstitutionsMarch 8, 2012
  NOT-OD-12-021Update of Sample Interinstitutional AssuranceDecember 1, 2011
  NOT-OD-10-083Update of Sample Animal Welfare Assurance for Foreign InstitutionsApril 16, 2010
  NOT-OD-08-049Update of Sample Animal Welfare AssuranceFebruary 15, 2008
  OPRR Reports 94-01Internal Distribution of Your Animal Welfare AssuranceJanuary 11, 1994

   IACUC Composition, Functions, and Authority

 3/22/2024NOT-OD-24-076Guidance on Flexibilities for Conducting Semiannual Program ReviewMarch 22, 2024
  NOT-OD-24-075Guidance on Flexibilities for Conducting Semiannual Inspections of Animal FacilitiesMarch 22, 2024
  NOT-OD-15-109Guidance on Qualifications of IACUC Nonscientific and Nonaffiliated MembersJune 9, 2015
  NOT-OD-11-053Guidance to Reduce Regulatory Burden for IACUC Administration Regarding Alternate Members and Approval DatesMarch 18, 2011
  NOT-OD-06-052Guidance on Use of Telecommunications for IACUC MeetingsMarch 24, 2006
  NOT-OD-01-017Guidance Regarding Administrative IACUC Issues (alternate IACUC members, IACUC review at collaborating institutions) and Efforts to Reduce Regulatory BurdenFebruary 12, 2001
  OPRR Reports 97-03Maintenance of Properly Constituted IACUCsJune 2, 1997

  Institutional Reporting to OLAW

  NOT-OD-24-008Reminder: Annual Reports to the Office of Laboratory Animal Welfare due December 1, 2023October 11, 2023
 12/13/2021NOT-OD-23-004Reminder: Annual Reports to the Office of Laboratory Animal Welfare due December 1, 2022October 3, 2022
  NOT-OD-20-109Notice of Update to the Reporting Period of the Annual Report to OLAWMay 21, 2020
  NOT-OD-13-044Notice of Change to Electronic Submission of Final Noncompliance Reports to the Office of Laboratory Animal WelfareFebruary 21, 2013
  NOT-OD-12-148Guidance on Departures from the Provisions of the Guide for the Care and Use of Laboratory AnimalsSeptember 10, 2012
  NOT-OD-05-034Guidance on Prompt Reporting to OLAW under the PHS Policy on Humane Care and Use of Laboratory AnimalsFebruary 24, 2005

 Institutional Responsibilities

  NOT-OD-22-207OLAW Waivers to Conduct Semiannual Facility Inspections due to COVID-19 Will Expire October 1, 2022September 12, 2022
  NOT-OD-10-081Guidance on Confirming Appropriate Charges to NIH Awards during Periods of Noncompliance for Activities Involving AnimalsApril 15, 2010
  NOT-OD-07-044NIH Policy on Allowable Costs for Grant Activities Involving Animals when Terms and Conditions are not UpheldJanuary 26, 2007

  Memoranda of Understanding (MOUs)

  NOT-OD-20-095Notice of Memorandum of Understanding Between NIH and NASA Concerning Laboratory Animal WelfareApril 16, 2020
  NOT-OD-15-139Notice of Memorandum of Understanding Between NIH and NSF Concerning Laboratory Animal WelfareAugust 10, 2015
  NOT-OD-15-028Notice of Office of Laboratory Animal Welfare Policy on Shared Animal Welfare ConcernsDecember 1, 2014
  OPRR Reports 97-02NASA Principles for the Ethical Care and Use of AnimalsMay 30, 1997

   Policy and Regulation

  NOT-OD-20-143Grant and Contract Submission Requirements Regarding the Updated AVMA Guidelines for the Euthanasia of Animals: 2020 EditionJuly 13, 2020
  NOT-OD-20-132Public Comments on the Implementation of the Updated AVMA Guidelines for the Euthanasia of Animals: 2020 EditionJune 30, 2020
  NOT-OD-15-079Notice of Update to the Public Health Service Policy on Humane Care and Use of Laboratory AnimalsMarch 17, 2015
  NOT-OD-13-096Implementation of the Revised International Guiding Principles for Biomedical Research Involving AnimalsAugust 2, 2013
  NOT-OD-12-020Adoption and Implementation of the Guide for the Care and Use of Laboratory Animals: Eighth EditionDecember 2, 2011
  NOT-OD-10-102Update of the Guide for the Care and Use of Laboratory AnimalsJune 4, 2010
  NOT-OD-00-007Guidance Regarding Reduction of Regulatory BurdenDecember 21, 1999

   Protocol Review

  NOT-OD-22-006Notice of Clarification of Institutional Responsibilities Regarding NIH Grant to Protocol Congruence ReviewOctober 18, 2021
  NOT-OD-22-005
 
Notice of Clarification of Offeror Responsibilites Regarding Contract to Protocol Congruence ReviewOctober 18, 2021
  NOT-OD-14-126Guidance on Significant Changes to Animal ActivitiesAugust 26, 2014
  NOT-OD-10-128Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal ResearchSeptember 1, 2010
  NOT-OD-09-035Guidance to IACUCs Regarding Use of Designated Member Review (DMR) for Animal Study Proposal Review Subsequent to Full Committee Review (FCR)January 8, 2009
  NOT-OD-03-046Revised Guidance Regarding IACUC Approval of Changes in Personnel Involved in Animal ActivitiesJune 6, 2003
  OPRR Reports 90-01Use of Expedited Protocol Review Procedures by IACUCsMay 21, 1990

   Reports and Statements

  NOT-OD-21-022Notice of Office of Laboratory Animal Welfare Statement on Oversight of NIH-owned ChimpanzeesNovember 5, 2020
  NOT-OD-19-136Report on Reducing Administrative Burden for Researchers: Animal Care and Use in ResearchAugust 28, 2019
  NOT-OD-19-069Report on Site Visits to the Veterans Affairs Medical Centers with Focus on Canine Care and Use in ResearchJanuary 31, 2019
  NOT-OD-17-010Reports on Site Visits to the National Primate Research Centers and the Federally Supported Chimpanzee SanctuaryOctober 25, 2016
  NOT-OD-10-121Report on Site Visits to Chimpanzee Facilities and Associated Resources to Aid Grantee InstitutionsAugust 6, 2010

   Vertebrate Animals Section (VAS)

  NOT-OD-16-006Simplification of the Vertebrate Animals Section of NIH Grant Applications and Contract ProposalsOctober 13, 2015
  NOT-OD-10-049Instructions for Completion and Technical Evaluation of the Vertebrate Animal Section (VAS) in NIH Contract ProposalsApril 19, 2010
  NOT-OD-10-027Instructions for Completion and Peer Review of the Vertebrate Animal Section (VAS) in NIH Grant Applications and Cooperative AgreementsMarch 17, 2010

 

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