Adoption

• FAQ. Can IACUCs authorize the adoption of research animals as pets after the animals are no longer needed for study?
• P.I. eAlert.2009; No. 6. (PDF - 299 KB) Lab Rat O.K. as Pet?
• OLAW Online Seminar: The 4th R: Rehoming, Retirement and Release - June 13, 2019
• AVMA Research Dogs and Cats Adoption – Considerations for developing a research institutional adoption program

Alternatives to animals

• OLAW Online Seminar: Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information - December 9, 2021
• Podcast: Alternatives to Animals - November 18,  2020

Animal numbers

• FAQ. When and how should animals be tracked on approved protocols?
• Lab Animal 2024; 53(02). A Word from USDA and OLAW: The Weights of Refinement and Flexibility
• Lab Animal. 2023; 52(11).(PDF - 465.7 KB) A Word From OLAW and USDA: Research Gone A-Fowl
• Lab Animal. 2023; 52(09).(PDF - 1.19 MB) A Word From OLAW and USDA: Genetically Modified Mishaps  
• Lab Animal. 2016; 45(1). (PDF - 510 KB) When reducing numbers might increase pain.
• Lab Animal. 2010; 39(2). (PDF - 149 KB) Breeding without research.
• Lab Animal. 2006; 35(1). Should you count your mice before they're weaned?

Animal reuse

• Lab Animal. 2023; 52(09).(PDF - 1.19 MB) A Word From OLAW and USDA: Genetically Modified Mishaps 
• Lab Animal 2023; 52(03). (PDF - 778.46 KB) A Word From OLAW and USDA: Once Used, Twice Counted
• Lab Animal. 2008; 37(2). (PDF - 95 KB) Collaborative studies and animal reuse.
• Lab Animal. 2007; 36(3). (PDF - 71 KB) One animal, two protocols – an appropriate application of the 3Rs?

Animal transfer

• FAQ. May an investigator transfer animals and research to an institution different than the grantee institution?
• Lab Animal. 2023; 52(09).(PDF - 1.19 MB) A Word From OLAW and USDA: Genetically Modified Mishaps  
• Lab Animal. 2001; 30(3). A Pain in the Rat.

Emergency, weekend, and holiday care

• Lab Animal. 2011; 40(11). (PDF - 179 KB) Quick action for an injured mouse.

Environmental enrichment

• FAQ. Is social housing required for nonhuman primates when housed in a research setting?
• FAQ. Should positive reinforcement training be used for nonhuman primates?
• FAQ. May performance standards determine environmental enrichment issues?
• OLAW Online Seminar: Animal Welfare in High Containment or Barrier Facilities: Addressing Unique Challenges - June 9, 2022
• Lab Animal. 2020; 49(11). (PDF - 844.98 KB) Should a primate pair put asunder be reunited?
• NOT-OD-10-121. Report on Site Visits to Chimpanzee Facilities and Associated Resources to Aid Grantee Institutions
• OLAW Online Seminar: AC and OLAW Perspective on Nonhuman Primate Enrichment and Social Housing - June 11, 2010

Ethics

• OPRR Reports. 97-02, 5/30/1997. NASA Principles for the Ethical Care and Use of Animals
• OLAW Online Seminar: Rights, Regulatory Systems and Legal Revolution - September 21, 2017
• OLAW Online Seminar: Balancing Public Interests, Benefits, and Risks in Animal Research - June 9, 2016
• OLAW Online Seminar: Ethics and IACUC Responsibility - June 10, 2010

Euthanasia methods

• FAQ. Is the use of carbon dioxide an acceptable euthanasia agent?
• OLAW Online Seminar: Update on the AVMA Guidelines for the Euthanasia of Animals: 2020 Edition - September 10, 2020
• Lab Animal. 2013; 42(6). (PDF - 192 KB) Scientific justification for exemptions.
• OLAW Online Seminar: Field Euthanasia Methods for Wildlife - March 29, 2018

Expired materials

• FAQ. May investigators use expired pharmaceuticals, biologics, and supplies in animals?
• Lab Animal. 2018; 47(06). (PDF - 728 KB) What's the appropriate adjustment when an approved drug is in short supply?

Food/fluid regulation

• FAQ. May investigators restrict animals' food and fluid?

Housing practices/construction

• FAQ. Can performance standards be used in determining rodent housing practices including management of rodent breeding colonies?
• FAQ. May performance standards determine housing issues?
• FAQ. Can performance standards be used in determining rabbit housing practices?
• Lab Animal 2023; 52(04) (PDF - 797.08 KB) A Word From OLAW: Earthquake!
• Lab Animal 2023; 52(02) (PDF - 583.41 KB) A Word from OLAW: Compliant Cooperation for your Collaboration
• Lab Animal 2022; 51(11) (PDF - 709.5 KB) A Word from OLAW: The Risk of Hazards, Hypothetically
• OLAW Online Seminar: Animal Welfare in High Containment or Barrier Facilities: Addressing Unique Challenges - June 9, 2022
• Lab Animal. 2022; 51(02). (PDF - 896.03 KB) A Word from OLAW: When is a House a Home?
• Lab Animal. 2020; 49(11). (PDF - 844.98 KB) Should a primate pair put asunder be reunited?
• Lab Animal. 2020; 49(10). (PDF - 730.28 KB) Under construction: how to deal with noise and vibration in the animal facility?
• Lab Animal. 2020; 49(08). (PDF - 823.09 KB) Algae in abundance: au natural, or a violation Xenopus husbandry standards?
• Lab Animal. 2007; 36(10). (PDF - 165 KB) Considerations for determining optimal mouse caging density.
• OLAW Online Seminar: Housing Laboratory Rodents According to the 8th Edition of the Guide - July 19, 2012

Mouse ascites

• FAQ. Is the mouse ascites method an acceptable method of monoclonal antibody production?
• NOT-OD-00-019. Office of Extramural Research Guidance Concerning the Production of Monoclonal Antibodies in Animals
• OPRR Reports. 98-01, 11/17/1997. Production of Monoclonal Antibodies Using Mouse Ascites Method

Multiple survival surgeries

• FAQ. Are major multiple survival surgical procedures permitted on a single animal?
• FAQ. Are laparoscopic procedures considered major surgery?
• Lab Animal eAlert. 2010; No. 17. (PDF - 336 KB) Is a laparoscopic serial liver biopsy considered ‘major' animal surgery?
• Contemporary Topics. 1997; 36(2):47-50, question #5.

Non-pharmaceutical-grade substances

• FAQ. May investigators use non-pharmaceutical-grade substances in animals?
• Lab Animal. 2019; 48(01) (PDF - 742 KB) Reply to "Clarification on a contradiction"
• Lab Animal. 2018; 47(06). (PDF - 728 KB) What's the appropriate adjustment when an approved drug is in short supply?
• OLAW Online Seminar: Regulatory Considerations for Using Pharmaceutical Products in Research Involving Laboratory Animals - June 4, 2015
• Lab Animal. 2003; 32(9):33-36, question #3.

Shipping

• FAQ. What are the institution's responsibilities in ensuring that animals are shipped safely and in reporting adverse events that occur in shipment of animals to or from the institution?

Surgery

• FAQ. What are the requirements for conducting rodent survival surgery?
• Lab Animal. 2010; 39(8). (PDF- 170 KB) Noncompliance in survival surgery technique.
• ILAR News. 1993; 35(3-4):47-49, question #1.

Distribution within institution

• OPRR Reports. 94-01, 1/11/1994, Internal Distribution of Your animal Welfare Assurance

Foreign Assurances

• NOT-OD-13-096. Implementation of the Revised International Guiding Principles for Biomedical Research Involving Animals
• NOT-OD-12-081. Change in Criteria for Renewal of Animal Welfare Assurances for Foreign Institutions
• NOT-OD-10-083. Update of Sample Animal Welfare Assurance for Foreign Institutions

Period of Approval

• NOT-OD-14-099. Notice of Change in Criteria for Renewal of Domestic Animal Welfare Assurances
• NOT-OD-04-052. Office of Extramural Research Notice Regarding Animal Welfare Documents Submitted to the Office of Laboratory Animal Welfare 

Sample Assurance document

• NOT-OD-21-130. Notice to Encourage Using AAALAC International Program Description Sections to Complete Parts of the OLAW Domestic Animal Welfare Assurance
• NOT-OD-10-083. Update of Sample Animal Welfare Assurance for Foreign Institutions
• NOT-OD-08-049. Update of Sample Animal Welfare Assurance
• Podcast: Animal Welfare Assurances - June 29, 2022
• OLAW Online Seminar: Writing a Good Assurance - June 9, 2011

Terms & conditions

• NOT-OD-10-081. Guidance on Confirming Appropriate Charges to NIH Awards during Periods of Noncompliance for Activities Involving Animals
• NOT-OD-07-044. NIH Policy on Allowable Costs for Grant Activities Involving Animals when Terms and Conditions are not Upheld
• OLAW Online Seminar: When Terms and Conditions Are Not Met - December 4, 2008
• Lab Animal eAlert. 2010; No. 6 (PDF- 334 KB) What is Protocol for Reporting an Animal-Research Project Exceeding Its Expiration Date?
• Lab Animal eAlert. 2010; No. 13 (PDF - 236 KB) Making charges to grants during an expiration period.

Veterinary care

• Lab Animal. 2020; 49(11). (PDF - 844.98 KB) Should a primate pair put asunder be reunited?
• Lab Animal. 2020; 49(10). (PDF - 730.28 KB) Under construction: how to deal with noise and vibration in the animal facility?
• Lab Animal. 2016; 45(5). (PDF - 590 KB) A hairy surgery.
• Lab Animal. 2011; 40(11). (PDF - 179 KB) Quick action for an injured mouse.
• Lab Animal. 2011; 40(8). (PDF - 209 KB) Power struggle between part-time employees.
• Lab Animal. 2009; 38(4). (PDF- 208 KB) Multiple campuses, one IACUC: how many AVs?
• Contemporary Topics. 1997; 36(2):47-50, question #4.

Animal tissue or materials

• FAQ. Does the PHS Policy apply to use of animal tissue or materials obtained from dead animals?
• Lab Animal. 2015; 44(4). (PDF - 650 KB) Congruence between grants and protocols.
• Lab Animal. 2010; 39(3). (PDF - 88 KB) Tissues from privately owned dogs.
• Lab Animal. 1997; 26(3). Optimal Animal Use.

Amphibians and fish

• FAQ. Does the PHS Policy apply to larval forms of amphibians and fish?
• FAQ. When and how should animals be tracked on approved protocols?
• Zebrafish 2016. 13(6):1-2. (PDF - 83 KB) OLAW Comments: Hatching Fish--When should animal tracking begin?

Clinical studies

• FAQ. How can the IACUC determine if activities involving privately owned animals constitute veterinary clinical care or research activities?
• Lab Animal. 2022. 51(10). (PDF - 854.9 KB) How do you Zoo?
• Lab Animal. 2022; 51(01). (PDF - 828.21 KB) Discretionary Consent.
• Lab Animal. 2016; 45(7). (PDF - 211 KB) When does ‘animal involvement’ become ‘animal use’?
• Lab Animal. 2010; 39(3). (PDF - 88 KB) Tissues from privately owned dogs.
• Lab Animal. 2009; 38(6). (PDF - 188 KB) Clinical study or research activity?

Custom services

• OPRR Reports. 95-02, 3/8/1995. Sources of Custom Antibody Production
• FAQ. Does the PHS Policy apply to the production of custom antibodies, or to the purchase of surgically modified animals?
• Lab Animal. 2012; 41(4). Amending a protocol to import and breed knockout mice.
• Lab Animal. 2003; 32(9): 33-36, question #5.
• Lab Animal. 2003; 32(9): 33-36, question #6.
• Lab Animal. 1995; 24(9):24-26, question #2.

Embryonated eggs

• FAQ. Does the PHS Policy apply to live embryonated eggs?
• ILAR News. 1991; 33(4):68-70, question #1.

Field studies

• FAQ. Does the PHS Policy apply to animal research that is conducted in the field?
• Lab Animal. 2023; 52(11).(PDF - 465.7 KB) A Word From OLAW and USDA: Research Gone A-Fowl
• Lab Animal. 2022. 51(10). (PDF - 854.9 KB) How do you Zoo?
• Lab Animal. 2022. 51(7). (PDF - 1013.21 KB) The IACUC's Wild Classification

Non-PHS funded activities

• FAQ. Should institutions apply the PHS Policy to all animal activities regardless of the source of funding?
• Lab Animal. 2024; 53(01). (PDF - 960.68 KB) A Word from OLAW: Emotional Support for Everyone
• Lab Animal. 2022. 51(10). (PDF - 854.9 KB) How do you Zoo?
• Lab Animal. 2014; 43(4). (PDF - 138 KB) Using privately owned animals in a study of human subjects.
• Lab Animal. 1995; 24(9):24-26, question #5.
• ILAR News. 1991; 33(4):68-70, question #2.

Privately owned animals

• FAQ. Does the IACUC need to approve research studies that use privately owned animals, such as pets?
• FAQ. How can the IACUC determine if activities involving privately owned animals constitute veterinary clinical care or research activities?
• Lab Animal. 2024; 53(01). (PDF - 960.68 KB) A Word from OLAW: Emotional Support for Everyone
• Lab Animal. 2022; 51(01). (PDF - 828.21 KB) Discretionary Consent.
• Lab Animal. 2020; 49(9). (PDF - 756 KB) Does a problem involving a pet cat require a report to regulators?
• Lab Animal. 2019; 48(3). (PDF - 775 KB) Showtime! Should an IACUC oversee companion animal exhibition activities on campus?
• Lab Animal. 2018; 47(5). (PDF - 802 KB) Protocols for pets: what authority does an IACUC have?
• Lab Animal. 2016; 45(7).  (PDF - 211 KB) When does ‘animal involvement’ become ‘animal use’?
• Lab Animal. 2014; 43(4). (PDF - 138 KB) Using privately owned animals in a study of human subjects.
• Lab Animal. 2010; 39(3). (PDF - 88 KB) Tissues from privately owned dogs.
• Lab Animal. 2009; 38(6). (PDF - 188 KB) Clinical study or research activity?
• Lab Animal. 2006; 35(6). (PDF - 71 KB) Clinical trial trouble.
• Lab Animal. 2003; 32(10). (PDF - 96 KB) Dog as Sculpture Models: Is IACUC Review Needed?

Alternate members

• Lab Animal 2023; 52(07) (PDF - 888.31 KB) A Word from OLAW and USDA: A Member by Any Other Name is...an Alternate?
• FAQ B.2. May the IACUC have alternate members? 
• NOT-OD-11-053. Guidance to Reduce Regulatory Burden for IACUC Administration Regarding Alternate Members and Approval Dates

Attendance

• FAQ B.4. Is a certain level of meeting attendance required of IACUC members?

Authority

• FAQ B.6. Does the IACUC have authority over activities not supported by PHS?
• Lab Animal 2023; 52(05) (PDF - 779.49 KB) A Word from OLAW and USDA: Customer Inconvenience for Regulatory Convenience
• Lab Animal 2023; 52(04) (PDF - 797.08 KB) A Word From OLAW: Earthquake!
• Lab Animal. 2009; 38(6). (PDF - 188 KB) Clinical study or research activity?
• Lab Animal. 1995; 24(9):24-26, question #6.

Change in scope

• FAQ B.13. Does OLAW expect the IACUC to notify NIH when there is a change in an animal activity supported by PHS funds?
• Lab Animal 2019; 48(10). (PDF - 665 KB) Pressure’s on: is it time to move ahead with nonhuman primates?

Composition

• FAQ B.3. Must certain members be present in order to conduct official business?
• Lab Animal. 2014; 43(2). (PDF - 219 KB) An IACUC Chair who isn't a member.
• ILAR News. 1991; 33(4):68-70, question #3.

Confidentiality

• Lab Animal 2020; 49(7). (PDF - 723.88 KB) Confidentiality & conflict: can one member serve two IACUCs?
• Lab Animal 2016; 45(9). (PDF - 577 KB) What are the limits of confidentiality for IACUC members?
• ILAR Journal. 1995; 37(4). Use of Electronic Communications for IACUC Functions.

Electronic communications

• FAQ B.8. May an IACUC conduct business on a teleconference call? 
• NOT-OD-06-052. Guidance on Use of Telecommunications for IACUC Meetings under the PHS Policy on Humane Care and Use of Laboratory Animals.
• Lab Animal. 2005; 34(2). Electronic (Mis)Communication in IACUC Procedures.
• Contemporary Topics. 2001; 40(6). Suggestions to Bring Electronic Protocol System into Compliance.
• ILAR Journal. 1995; 37(4). Use of Electronic Communications for IACUC Functions.

Financial compensation

• FAQ B.11. May the institution pay or reimburse expenses incurred by nonaffiliated members?
• ILAR News. 1991; 33(4):68-70, question #4.

Institutional Officials

• FAQ B.10. Does the Institutional Official have authority to halt an activity that was previously approved by the IACUC, or to approve one that was not initially approved by the IACUC?
• Lab Animal 2019; 48(10). (PDF - 665 KB) Pressure’s on: is it time to move ahead with nonhuman primates?
• Lab Animal 2014; 43(8). (PDF - 599 KB) Animal care and use programs for multiple campuses
• Lab Animal 2012; 41(3). (PDF - 181 KB) Disagreement between IO and IACUC.
• Lab Animal 2003; 32(9). A Mouse Isn’t a Rat, But What’s the Big Deal?
• Lab Animal 1998; 27(9). The Unofficial Official?

Membership

• FAQ B.1. What are the IACUC membership criteria?
• Lab Animal. 2009; 38(4). (PDF - 208 KB) Multiple campuses, one IACUC: how many AVs?
• Lab Animal. 2003; 32(9):33-36, question #7.
• Contemporary Topics. 1997; 36(2):47-50, question #3.
• OPRR Reports. 97-03, 6/2/1997. Maintenance of Properly Constituted IACUCs.
• ILAR News. 1993; 35(3-4):47-49, question #4.

Minutes

• FAQ B.7. What information should be in IACUC minutes?
• Lab Animal. 2015; 44(5). (PDF - 723 KB) A Word from OLAW and USDA. Should the chairperson control IACUC meeting minutes?
• Lab Animal. 2010; 39(10). (PDF - 189 KB) Is electronic approval appropriate?

Nonscientific and Nonaffiliated (Unaffiliated) Members

Terminology: May also be known as non-scientific and non-affiliated members.

• FAQ B.1. What are the IACUC membership criteria?
• FAQ B.11. May the institution pay or reimburse expenses incurred by nonaffiliated members?
• FAQ B.12. How does OLAW define nonscientific IACUC member?
• FAQ B.14. How does OLAW define nonaffiliated IACUC member?
• FAQ B.15. May one individual fulfill the requirement for both a nonaffiliated and a nonscientific member?
• NOT-OD-15-109. Guidance on Qualifications of IACUC Nonscientific and Nonaffiliated Members
• OPRR Reports 97-03 Maintenance of Properly Constituted IACUCs
• Lab Animal 2020; 49(7). Confidentiality & conflict: can one member serve two IACUCs?
• Lab Animal 2005; 34(1). Alternate IACUC Members: What Are the Rules?
• Lab Animal. 2003; 32(9):33-36, question #7.
• Contemporary Topics 1997 36(2):47-50, questions 3-4
• OLAW Webinar: OLAW Online Office Hour

Quorum

• FAQ B.5. What is a quorum and when is a quorum required?
• Lab Animal. 1996; 25(5). Majority Rules?

Review of concerns

• Lab Animal. 2020; 49(6). (PDF - 746 KB) What's in store for a whistleblower?
• Lab Animal. 2011; 40(1). (PDF - 156 KB) From ‘Designated Member’ back to ‘Full Committee’?
• Lab Animal. 2010; 39(6). (PDF - 180 KB) Revisiting approved protocols.

Suspensions

• FAQ B.9. May an IACUC suspend (stop) animal activities that it did not initially approve?
• Lab Animal. 2023; 52(10) (PDF - 836.9 KB) Respect for the PI’s Ultimate Responsibility
• Lab Animal. 2023; 52(01) (PDF - 897.04 KB) Suspended in Terminated Access.
• Lab Animal. 2022; 51(09). (PDF - 649.24 KB) A Word from OLAW: You've Been Approved to Wait
• Lab Animal. 2019; 48(9). (PDF - 798 KB) A late notice & personal conflict - was a suspension warranted?
• Lab Animal. 2019; 48(8). (PDF - 782 KB) On hold: what to report after a study is halted?
• Lab Animal. 2013; 42(7). (PDF - 186 KB) Terms of Suspension.
• Lab Animal. 2012; 41(9). (PDF - 160 KB) Reactivation of a suspended protocol.
• Lab Animal. 2010; 39(8). (PDF - 170 KB) Noncompliance in survival surgery technique.
• Lab Animal. 2009; 38(2). (PDF - 112 KB) Reportability of protocol suspensions.
• Lab Animal. 2006; 35(10). (PDF - 87 KB) Tackling investigator noncompliance.
• Lab Animal. 1998; 27(9). The Unofficial Official?

Annual Reports

• FAQ. What is the annual report to OLAW and when is it due?
• OLAW Online Seminar: Update to the Reporting Period of the Annual Report to OLAW - June 17, 2020
• NOT-OD-20-109. Notice of Update to the Reporting Period of the Annual Report to OLAW
• NOT-OD-04-052. Office of Extramural Research Notice Regarding Animal Welfare Documents Submitted to the Office of Laboratory Animal Welfare
• ILAR News. 1993; 35(3-4):47-49, question #6.

Departures

• FAQ. What are PHS Policy reporting requirements for departures from the Guide?
• NOT-OD-12-148. Guidance on Departures from the Provisions of the Guide for the Care and Use of Laboratory Animals
• OLAW Online Seminar: Departures from the Guide - October 4, 2012
• OLAW Webpage: Departures from the Guide

Freedom of Information Act - FOIA

• FAQ. Are institutions required by FOIA to release information about their research, animal care programs, and IACUCs?
• FAQ. Are all documents submitted to OLAW subject to the Freedom of Information Act?
• OLAW Online Seminar: Developments in FOIA in the Context of Animal Research - December 10, 2020
• OLAW Online Seminar: Openness and Transparency and Biomedical Research Oversight - December 4, 2014
• OLAW Online Seminar: Freedom of Information Act Policies - September 18, 2008

Minority Views

• FAQ. What are PHS requirements for recording and reporting minority views?

Reporting Noncompliance

• FAQ. What kinds of situations should be reported to OLAW under IV.F.3. of the PHS Policy, and when, where, and how should they be reported?
• NOT-OD-05-034. Guidance on Prompt Reporting to OLAW under the PHS Policy on Humane Care and Use of Laboratory Animals
• Lab Animal 2023; 52(06). Response from OLAW: Buffering from Approval to Implementation
• Lab Animal 2023; 52(04). A Word From OLAW: Earthquake!
• Lab Animal 2022; 51(06). The Matters of an Occupational Health and Safety Program
• Lab Animal. 2022; 51(05). Administrative Non-Compliance?
• Lab Animal. 2020; 49(10). Under construction: how to deal with noise and vibration in the animal facility?
• Lab Animal. 2020; 49(9). Does a problem involving a pet cat require a report to regulators?
• Lab Animal. 2020; 49(6). What's in store for a whistleblower?
• Lab Animal. 2019; 48(8). On hold: what to report after a study is halted?
• Lab Animal. 2018; 47(3). Post-publication problems: how to proceed when there’s no record of IACUC approval?
• Lab Animal. 2018; 47(2). How should the IACUC handle unanticipated deaths?
• Lab Animal. 2017; 46(7). What does “reporting to the IACUC” mean for PAM?
• Lab Animal. 2016; 45(11). Who should decide when and how to contact OLAW?
• Lab Animal. 2013; 42(7). Terms of Suspension.
• Lab Animal. 2013; 42(4). Communication between collaborating IACUCs.
• Lab Animal. 2013; 42(3). Should 'duplicative research' still be reviewed?
• Lab Animal. 2012; 41(3). Disagreement between IO and IACUC.
• Lab Animal. 2011; 40(3). Miscommunication involving ‘standard care’.
• Lab Animal. 2011; 40(2). Citation for a discussion of noncompliance.
• Lab Animal. 2010; 39(8).  Noncompliance in survival surgery technique.
• Lab Animal eAlert. 2010 (6). What is Protocol for Reporting an Animal-Research Project Exceeding Its Expiration Date?
• Lab Animal. 2009; 38(11). Categorizing insufficient pain alleviation.
• Lab Anima)l. 2009; 38(2. Reportability of protocol suspensions.
• Lab Animal. 2003; 32(9). A Mouse Isn’t a Rat, But What’s the Big Deal?
• Lab Animal. 2002; 31(5). To Report or Not to Report?
• Lab Animal. 1995; 24(9):24-26, question #4.
• OLAW Online Seminar: Self-Evaluation & Reporting: Always Let the Guide be Your Conscience - December 15, 2016
• OLAW Online Seminar: Reporting Noncompliant Events to OLAW - March 5, 2009
• OLAW Webpage: Reporting Noncompliance

Sanctions & Suspensions

• FAQ. Should the IACUC report sanctions other than suspensions that are imposed by the Committee or by other institutional officials?
• Lab Animal. 2023; 52(10) Respect for the PI’s Ultimate Responsibility
• Lab Animal. 2023; 52(01) Suspended in Terminated Access.
• Lab Animal. 2013; 42(7). Terms of Suspension.
• Lab Animal. 2011; 40(3). Miscommunication involving ‘standard care’.
• Lab Animal. 2010; 39(8). Noncompliance in survival surgery technique.
• Lab Animal. 2009; 38(2). Reportability of protocol suspensions.
• Lab Animal. 2006; 35(10). Tackling investigator noncompliance.
• ILAR News. 1993; 35(3-4):47-49, question #5.

Administrative organization

• FAQ. What kind of administrative organization works best for ensuring compliance?
• Lab Animal 2017; 46(7). (PDF - 541 KB) What does “reporting to the IACUC” mean for PAM?
• Lab Animal. 2009; 38(4). (PDF - 208 KB) Multiple campuses, one IACUC: how many AVs?
• ILAR News. 1993; 35(3-4):68-70, question #2.
• OLAW Online Seminar: Preparing for Animal Rights Extremist Activities at Your Institution - June 12, 2008

Agricultural animals / livestock

• FAQ. May institutions utilize the Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (Ag Guide) if their program includes traditional farm animals?
• Lab Animal. 2019; 48(2). (PDF - 705 KB) All in the barn: who oversees agricultural research animals?
• Lab Animal. 2006; 35(4). (PDF - 85 KB) Conference wet lab: is an IACUC needed?

Animal activism

• FAQ. What are the institution's responsibilities in preparing for targeting by animal rights activists?
• OLAW Online Seminar: Animal Research and Public Support: A 2020 Vision for Strategic Communications and Micro-Messaging - June 11, 2020
• OLAW Online Seminar: Preparing for Animal Rights Extremist Activities at Your Institution - June 12, 2008

Appointment of IACUC

• Lab Animal. 2007; 36(2). (PDF - 74 KB) New CEO, new IACUC?

Compliance

• Lab Animal. 2020; 49(6). (PDF - 746 KB) What's in store for a whistleblower?
• Lab Animal. 2006; 35(10). (PDF - 87 KB) Tackling investigator noncompliance.
• Lab Animal. 2000; 29(5). (PDF) Common Areas of Noncompliance.
• Lab Animal. 1994; 23(8). Compliance at the Institutional Level.
• OLAW webpage: Reporting Noncompliance

Cost

• FAQ. May cost be used as justification for not implementing animal welfare standards?
• Lab Animal 2014; 43(3). (PDF - 192 KB) Rationale for new model development.  

Disaster plans & emergencies

• FAQ. How can institutions and their IACUCs best prepare for a disaster or emergency?
• FAQ. Do awardee institutions need animal facility disaster plans?
• FAQ. How can institutions assure animal welfare when HVAC systems malfunction or fail?
• Laboratory Animal Science Professional 2020; 8(6) (PDF - 798.11 KB). Veterinary Staffing Shortages and Potential Solutions During the COVID-19 Pandemic. This article appeared in the AALAS membership magazine, Laboratory Animal Science Professional, November - December 2020, and is reprinted by permission. 
• Lab Animal. 2017; 46(6) (PDF - 496 KB). Adverse events at research facilities.
• Lab Animal. 2002; 31(8). Disaster Recovery: "Who ya gonna call?”
• PI eAlert. 2010; No. 8 (PDF - 322 KB) How Can I Prepare My Animal-Research Lab for an Earthquake?
• OLAW Online Seminar: Disaster Preparedness and Response - September 26, 2024
• OLAW Online Seminar: Application of the AVMA Guidelines for the Depopulation of Animals to Biomedical Research - September 26, 2019
• OLAW Online Seminar: Disaster Planning - March 7, 2013
• OLAW Online Seminar: Preparing for Animal Rights Extremist Activities at Your Institution - June 12, 2008
• OLAW webpage: Disaster Preparedness and Response

IO vs. CEO

• FAQ. What is the difference between the Institutional Official and the Chief Executive Officer?
• Contemporary Topics. 1997; 36(2):47-50, question #3.

Occupational health & safety

• FAQ. What is required for an occupational health and safety program?
• Lab Animal 2023; 52(02) (PDF - 583.41 KB) A Word from OLAW: Compliant Cooperation for your Collaboration
• Lab Animal 2022; 51(11). (PDF - 709.5 KB) A Word from OLAW: The Risk of Hazards, Hypothetically
• Lab Animal 2022; 51(09). (PDF - 649.24 KB) A Word from OLAW: You've Been Approved to Wait
• Lab Animal 2022; 51(06). (PDF - 625.16 KB) The Matters of an Occupational Health and Safety Program
• Lab Animal 1995; 24(9). 24-26, question #7.
• OLAW Online Seminar: Building a Research Occupational Health Program - March 12, 2020

Pandemic (COVID-19)

Important: COVID-19 specific text no longer represents current NIH policy. Pandemic information in place prior to the end of the public health emergency is maintained for historical purposes only. Please refer to current guidance and FAQs on disaster preparedness and emergencies.

• Laboratory Animal Science Professional 2020; 8(6) (PDF - 798.11 KB). Veterinary Staffing Shortages and Potential Solutions During the COVID-19 Pandemic. This article appeared in the AALAS membership magazine, Laboratory Animal Science Professional, November - December 2020, and is reprinted by permission. 
• Laboratory Animal Science Professional 2020; 8(4) (PDF - 1.23 MB). Maintaining Compliance in Unprecedented Times: Flexibilities for Compliance with the PHS Policy During the COVID-19 Pandemic. This article appeared in the AALAS membership magazine, Laboratory Animal Science Professional, July - August 2020, and is reprinted by permission. 
• Lab Animal 2020; 49(05). (PDF - 505 KB). A Word from OLAW: COVID-19 guidance
• OLAW Online Seminar: COVID-19 Pandemic Response Resources and FAQs for Animal Care and Use Programs - April 8, 2020
• OLAW Online Seminar: Pandemic Contingency Planning and Its Impact on Animal Care - March 19, 2020

Performance standards

• FAQ. What is OLAW's position on performance standards?
• FAQ. May performance standards determine housing issues?
• FAQ. May performance standards determine environmental enrichment issues?
• Lab Animal. 2022; 51(2). (PDF - 896.03 KB) When is a House a Home?
• OLAW Online Seminar: Performance Standards - April 19, 2012

Post-approval monitoring

• FAQ. Is post approval monitoring required?
• Lab Animal 2022; 51(3). (PDF - 846.59 KB) A Word from OLAW: Renewed Responsibility
• Lab Animal 2021; 50(11). (PDF - 703 KB) Documentation on personnel training.
• Lab Animal 2019; 48(11). (PDF - 659 KB) Cardiac surgeon wanted: mouse experience required?
• Lab Animal 2018; 47(02). (PDF - 547 KB) How should the IACUC handle unanticipated deaths?
• Lab Animal 2017; 46(7). (PDF - 541 KB) What does “reporting to the IACUC” mean for PAM?
• Lab Animal 2016; 45(10). (PDF - 968 KB) How should an IACUC handle high mortality rates?
• Contemporary Topics. 1996; 35(5). Model for Performing Institutional Animal Care and Use Committee: Continuing Review of Animal Research.

Training of staff

• FAQ. What kind of training is necessary to comply with the PHS Policy and how frequently should it be provided?
• Lab Animal 2023; 52(05) (PDF - 779.49 KB) A Word from OLAW and USDA: Customer Inconvenience for Regulatory Convenience
• Lab Animal 2021; 50(11). (PDF - 703 KB) Documentation on personnel training.
• Laboratory Animal Science Professional 2020; 8(6) (PDF - 798.11 KB). Veterinary Staffing Shortages and Potential Solutions During the COVID-19 Pandemic. This article appeared in the AALAS membership magazine, Laboratory Animal Science Professional, November - December 2020, and is reprinted by permission.
• Lab Animal 2019; 48(11). (PDF - 659 KB) Cardiac surgeon wanted: mouse experience required?
• Lab Animal 2016; 45(10). (PDF - 968 KB) How should an IACUC handle high mortality rates?
• Lab Animal. 2010; 39(8). (PDF - 170 KB) Noncompliance in survival surgery technique.
• Lab Animal. 1995; 24(9):24-26, question #3.
• OLAW Online Seminar: Superstar Rats Teach Empathy to Researchers - March 21, 2019
• OLAW Online Seminar: Training Issues - June 20, 2013

• OLAW Online Seminar: 21st Century Cures Act: Updates and Your Questions Answered - March 10, 2022
• OLAW Online Seminar: 21st Century Cures Act: Update on Implementation - March 11, 2021
• NOT-OD-20-143: Grant and Contract Submission Requirements Regarding the Updated AVMA Guidelines for the Euthanasia of Animals: 2020 Edition
• NOT-OD-16-006: Simplification of the Vertebrate Animals Section of NIH Grant Applications and Contract Proposals
• NOT-OD-10-128. Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal Research
• NOT-OD-10-049. Instructions for Completion and Technical Evaluation of the Vertebrate Animal Section (VAS) in NIH Contract Proposals
• NOT-OD-10-027. Instructions for Completion and Peer Review of the Vertebrate Animals Section (VAS) in NIH Grant Applications and Cooperative Agreements
• “Just-In-Time”. Federal Register, 8/7/2002, 67 FR 51289 (PDF)
• OLAW Online Seminar: OLAW Office Hour - December 3, 2015
• OLAW Online Seminar: IACUC Responsibilities Beyond Protocol Review and Facilities Inspection - March 10, 2011
• OLAW Online Seminar: IACUC Review of Proposed Animal Activities - December 9, 2010
• OLAW Online Seminar: Discussion of OLAW FAQs - September 9, 2010
• OLAW Online Seminar: Emerging Issues, USDA Perspective – September 17, 2009

  NOT-OD-24-076. Guidance on Flexibilities for Conducting Semiannual Program Review

AAALAC evaluations

• FAQ. May the IACUC use an AAALAC International site visit as its semiannual evaluation?
• OLAW Online Seminar: What Every IACUC Should Know About AAALAC International - September 9, 2021
• NOT-OD-00-007. Office of Extramural Research Guidance Regarding Reduction of Regulatory Burden in Laboratory Animal Welfare
• OLAW Online Seminar: What Every IACUC Should Know About AAALAC International - June 11, 2009

Deficiencies

• FAQ. How does the IACUC distinguish between significant and minor deficiencies?
• Lab Animal 2022; 51(3). (PDF - 846.59 KB) A Word from OLAW: Renewed Responsibility
• Lab Animal 2020; 49(8). (PDF - 823.09 KB) Algae in abundance: au natural, or a violation Xenopus husbandry standards?
• Lab Animal 2012; 41(3). (PDF - 181 KB) Disagreement between IO and IACUC.
• Contemporary Topics. 1997; 36(2):47-50, question #1.

Field sites

• FAQ. Is the IACUC required to inspect field study sites?

Laboratory inspections

• FAQ. Should the IACUC inspect laboratories or other sites where investigators use animals?
• NOT-OD-24-075. Guidance on Flexibilities for Conducting Semiannual Inspections of Animal Facilities
• OLAW Online Seminar: Facility Inspections - June 28, 2018
• Lab Animal 2014; 43(5). (PDF - 582 KB) Temporary housing for hamsters.
• Contemporary Topics. 1997; 36(2):47-50, question #8.
• ILAR News. 1991; 33(4):68-70, question #5.
• ILAR News. 1991; 33(4):68-70, question #6.

Physical plant

• OLAW Online Seminar: Physical Plant Issues - March 11, 2010

Standard operating procedures

• Lab Animal 2022; 51(3). (PDF - 846.59 KB) A Word from OLAW: Renewed Responsibility
• Lab Animal 2012; 41(2). (PDF - 98 KB) IACUC approval of SOPs.

Approval date

• NOT-OD-11-053. Guidance to Reduce Regulatory Burden for IACUC Administration Regarding Alternate Members and Approval Dates
• FAQ. What is the date of IACUC approval of an animal activity?

Approval of extensions

• FAQ. May the IACUC administratively extend approval of a project that has expired?
• Lab Animal. 2012; 41(8). (PDF - 96 KB) Management of a holding protocol.
• Lab Animal. 2010; 39(11). (PDF - 178 KB) Refusal to renew an expiring protocol.
• Lab Animal. 2007; 36(7). (PDF - 60 KB) Getting around late protocol renewals.
• Lab Animal. 2003; 32(9):33-36, question #8.

Approval methods

• FAQ. What are the possible methods of IACUC approval?
• Lab Animal. 2022; 51(08). (PDF - 730.56 KB) When Assigned but Now Unavailable
• Lab Animal. 2017; 46(11). (PDF - 544 KB) How should the IACUC balance an efficient approval process with minimizing risk?
• Lab Animal. 2011; 40(10). (PDF - 171 KB) Managing a pending IBC approval.
• Lab Animal. 2010; 39(6). (PDF - 180 KB) Revisiting approved protocols.
• Lab Animal. 2003; 32(9):33-36, question #4.
• Lab Animal. 2002; 31(9). Correct Conduct of Full-Committee and Designated Member Protocol Reviews.
• Contemporary Topics. 2001; 40(6). Suggestions to Bring Electronic Protocol System into Compliance.
• Lab Animal. 2001; 30(6). Is Ad Hoc Approval Enough?
• Lab Animal. 2001; 30(3). Innovative, But Not Compliant.
• Lab Animal. 1998; 27(8). So Much Work, So Little Time.
• ILAR News. 1993; 35(3-4):47-49, question #3.

Collaborating institutions

• FAQ. When institutions collaborate or when the performance site is not the grantee institution, which IACUC is responsible for review of the research activity?
• OLAW Online Seminar: MOUs for Collaborating Institutions: New Template from the Federal Demonstration-Partnership (FDP) - January 19, 2023
• Lab Animal. 2021; 50(1). (PDF - 736 KB) A COVID clash: How to proceed when IACUCs and IBCs disagree?
• Lab Animal. 2019; 48(1). (PDF - 733 KB) Misunderstanding of an MOU?
• Lab Animal. 2013; 42(4). (PDF - 159 KB) Communication between collaborating IACUCs.
• Lab Animal. 2009; 38(6). (PDF - 188 KB) Clinical study or research activity?

Conditional approvals

• FAQ. May the IACUC grant conditional or provisional approval?
• FAQ. May IACUCs allow designated reviewers to review and approve animal activities, thus allowing animal research to begin, before all IACUC members have had an opportunity to call for full committee review (FCR)?
• Lab Animal. 2022; 51(09). (PDF - 649.24 KB) A Word from OLAW: You've Been Approved to Wait
• Lab Animal. 2017; 46(11). (PDF - 544 KB)  How should the IACUC balance an efficient approval process with minimizing risk?
• Lab Animal. 2011; 40(10). (PDF - 171 KB) Managing a pending IBC approval.
• Lab Animal. 2008; 37(2). (PDF - 95 KB) Collaborative studies and animal reuse.
• Lab Animal. 2003; 32(9):33-36, question #2.
• OPRR Reports. 90-01, 5/21/1990. Use of Expedited Protocol Review Procedures by IACUCs.

Conflict of interest

• Lab Animal. 2019; 48(9). (PDF - 798 KB) A late notice & personal conflict - was a suspension warranted?
• Lab Animal. 2013; 42(3). (PDF - 246 KB) Should 'duplicative research' still be reviewed?
• Lab Animal. 2010; 39(6). (PDF - 180 KB) Revisiting approved protocols.

DMR & FCR

• FAQ. What are the possible methods of IACUC approval?
• FAQ. May an IACUC use designated member review (DMR) to review an animal study protocol subsequent to full committee review (FCR) when modifications are needed to secure approval?
• FAQ. May IACUC members call for FCR after the deadline for a response to allow DMR has passed?
• Lab Animal. 2022; 51(08). (PDF - 730.56 KB) When Assigned but Now Unavailable
• Lab Animal. 2021;50(10). (PDF - 689 KB) The Full Committee Review Plunder.
• Lab Animal. 2017; 46(4). (PDF - 533 KB) Who should request a full committee review?
• Lab Animal. 2015; 44(9). (PDF - 569 KB) Expediting assignment of protocol reviewers.
• Lab Animal. 2012; 41(11). (PDF - 144 KB) Amendment submitted; protocol reviewed?
• Lab Animal. 2009; 38(7). (PDF - 182 KB) Required modifications and designated member reviews.
• NOT-OD-09-035. Guidance to IACUCs Regarding Use of Designated Member Review (DMR) for Animal Study Proposal Review Subsequent to Full Committee Review (FCR).
• Lab Animal. 2002; 31(9). Correct Conduct of Full-Committee and Designated Member Protocol Reviews.

Foreign-derived samples

• FAQ. Is IACUC approval required for the collection of samples in foreign countries from captive wild animals or research colonies?

Foreign institutions

• FAQ. If an animal activity will be performed outside of the US (either by a non-US grantee or by a foreign institution as a subproject for a domestic grantee), is the grantee's IACUC required to review and approve that activity?
• NOT-OD-12-081. Change in Criteria for Renewal of Animal Welfare Assurances for Foreign Institutions
• Contemporary Topics. 1997; 36(2):47-50, question #2.

Frequency of review

• FAQ. How frequently should the IACUC review research protocols?
• Lab Animal. 2012; 41(11). (PDF - 144 KB) Amendment submitted; protocol reviewed?
• Lab Animal. 2000; 29(3). Problem Children.
• Contemporary Topics 1996; 35(5):53-56. Model for Performing Institutional Animal Care and Use Committee: Continuing Review of Animal Research.
• ILAR News. 1993; 35(3-4):47-49, question #7.

Grant review

• FAQ. Is the IACUC required to review the grant application?
• NOT-OD-22-006. Notice of Clarification of Offeror Responsibilities Regarding Contract to Protocol Congruence Review
• NOT-OD-22-005. Notice of Clarification of Institutional Responsibilities Regarding NIH Grant to Protocol Congruence
• OLAW Online Seminar: Congruence Review - January 18, 2024
• OLAW Online Seminar: The 2016 Vertebrate Animals Section, Grants Policy, and Congruence - March 10, 2016
• OLAW Online Seminar: Grants Policy and Congruence - June 7, 2012
• Lab Animal. 2020; 49(2). (PDF - 657 KB) Is reproducibility an IACUC’s concern?
• Lab Animal. 2015; 44(4). (PDF - 650 KB) Congruence between grants and protocols.
• Lab Animal. 2006; 35(2). Grants proposals and animal use protocols: Is the IACUC playing by the rules?
• Lab Animal. 2003; 32(9):33-36, question #1.
• Lab Animal. 1999; 28(7). Who's to Blame?

Humane endpoints

• Lab Animal. 2022; 51(04). (PDF - 881.87 KB) Delaying the Inevitable: a Justified Means to an End?
• OLAW Online Seminar: Monitoring for Humane Endpoints: Developing an Appropriate Strategy - September 20, 2018

Non-research activities

• FAQ. Is IACUC approval required for the use of animals in breeding programs, as blood donors, as sentinels in disease surveillance programs, or for other non-research purposes?
• OLAW Online Seminar: IACUC responsibilities regarding service animals - June 10, 2021
• Lab Animal. 2013; 42(9). (PDF - 136 KB) Using research animals as sentinels.
• Lab Animal. 2003; 32(10). (PDF - 96 KB) Dog as Sculpture Models: Is IACUC Review Needed?

Nontraditional species

• FAQ. What guidelines should IACUCs follow for fishes, amphibians, reptiles, birds, and other nontraditional species used in research?
• Lab Animal. 2023; 52(11).(PDF - 465.7 KB) A Word From OLAW and USDA: Research Gone A-Fowl
• Lab Animal. 2022. 51(7). (PDF - 1013.21 KB) The IACUC's Wild Classification
• Contemporary Topics. 1997; 36(2):47-50, question #6.
• OLAW Online Seminar: Wildlife Research Permits: What IACUCs Need to Know - March 30, 2017
• OLAW Online Seminar: Zebrafish 101 for IACUCs - March 12, 2015
• OLAW Online Seminar: Oversight of Research Involving Wildlife - March 20, 2014

Pilot studies

• FAQ. May the IACUC approve pilot studies?
• Lab Animal 2024; 53(02). A Word from USDA and OLAW: The Weights of Refinement and Flexibility
• Lab Animal 2022; 51(3). (PDF - 846.59 KB) A Word from OLAW: Renewed Responsibility
• Lab Animal 2020; 49(2). (PDF - 657 KB) Is reproducibility an IACUC’s concern?
• Lab Animal. 2016; 45(2). (PDF - 591 KB) Should refinement ‘mess with success’?
• Lab Animal. 2001; 30(3):21. A Pain in the Rat.

PIs

• FAQ. Is it acceptable to have different individuals named as PI on the grant application and the IACUC protocol?
• FAQ. What personnel changes qualify as significant changes to an animal activity, and which must be reported to the funding NIH Institute or Center (IC)?
• Lab Animal. 2018; 47(7). (PDF - 694 KB) Who gets to be a PI?
• Lab Animal. 2007; 36(1). (PDF - 73 KB) The importance of being ‘in charge'.

3 R's

• FAQ. Should the IACUC consider the three “Rs” of alternatives when reviewing protocols?
• OLAW Online Seminar: Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information - December 9, 2021
• Lab Animal 2024; 53(02). A Word from USDA and OLAW: The Weights of Refinement and Flexibility
• Lab Animal 2022; 51(03). (PDF - 846.59 KB) A Word from OLAW: Renewed Responsibility
• Lab Animal. 2020; 49(1). (PDF - 788 KB) If a researcher disagrees with a veterinarian's recommendations, whose say goes?
• Lab Animal. 2016; 45(2). (PDF - 591 KB) Should refinement ‘mess with success’?
• Lab Animal. 2016; 45(1). (PDF - 510 KB) When reducing numbers might increase pain.
• Lab Animal. 2010; 39(2). (PDF - 149 KB) Breeding without research.
• Lab Animal. 2009; 38(11). (PDF - 187 KB) Categorizing insufficient pain alleviation.
• Lab Animal. 2008; 37(7). (PDF - 95 KB) Deciding which animals to use.
• PI eAlert. 2010; Jul (PDF - 415 KB) Was McGill's “Mouse Pain” Study Compliant With Lab Animal Welfare?
• OLAW Online Seminar: The ARRIVE 2.0 Essential 10: Guidance for NIH-sponsored Research- June 15, 2023
• OLAW Online Seminar: Resources for the 3Rs - September 24, 2015
• OLAW Online Seminar: Meeting Requirements for Alternatives Searches - June 26, 2014

Review criteria

• FAQ. What criteria should the IACUC consider when reviewing protocols?
• Lab Animal. 2020; 49(1). (PDF - 788 KB) If a researcher disagrees with a veterinarian's recommendations, whose say goes?
• Lab Animal. 2014; 43(3). (PDF - 192 KB) Rationale for new model development.
• Lab Animal. 2013; 42(6). (PDF - 192 KB) Scientific justification for exemptions.
• Lab Animal. 2009; 38(7). (PDF - 182 KB) Required modifications and designated member reviews.
• OLAW Online Seminar: Improving Experimental Design: Ethical Implications and How the Experimental Design Assistant (EDA) Can Help - September 14, 2023
• OLAW Online Seminar: Foundations for Evaluating Study Design and Statistical Approaches for the IACUC -March 9, 2023

Scientific merit

• FAQ. Is the IACUC responsible for judging the scientific merit of proposals?
• Lab Animal. 2020; 49(2). (PDF - 657 KB) Is reproducibility an IACUC’s concern?
• Lab Animal. 2016; 45(1). (PDF - 510 KB) When reducing numbers might increase pain.
• ILAR News. 1991; 33(4):68-70, question #7.

Significant changes

• FAQ. What is considered a significant change to a project that would require IACUC review?
• FAQ. Does OLAW expect the IACUC to notify NIH when there is a change in an animal activity supported by PHS funds?
• FAQ. What personnel changes qualify as significant changes to an animal activity, and which must be reported to the funding NIH Institute or Center (IC)?
• NOT-OD-14-126: Guidance on Significant Changes to Animal Activities
• Lab Animal. 2023; 52(12). (PDF - 793.32 KB) A Word from the USDA and OLAW: The Pain and Distress of VVC.
• Lab Animal. 2022; 51(04). (PDF - 881.87 KB) Delaying the Inevitable: a Justified Means to an End?
• Lab Animal. 2019; 48(1). (PDF - 733 KB) Misunderstanding of an MOU?
• Lab Animal. 2019; 48(1). (PDF - 742 KB) Reply to "Clarification on a contradiction"
• Lab Animal. 2018; 47(6). (PDF - 728 KB) What's the appropriate adjustment when an approved drug is in short supply?
• Lab Animal. 2018; 47(4). (PDF - 773 KB) Is ‘saving money’ a valid justification?
• Lab Animal. 2018; 47(1). (PDF - 521 KB) How should the IACUC handle a questionable VVC change to a protocol? 
• Lab Animal. 2017; 46(3). (PDF - 467 KB) Making changes: when is VVC appropriate?
• Lab Animal. 2016; 45(8). (PDF - 568 KB) Referencing an approved protocol in an amendment.
• Lab Animal. 2015; 44(3). (PDF - 620 KB) Interpreting guidance on significant changes.
• Lab Animal. 2012; 41(4). (PDF - 155 KB) Amending a protocol to import and breed knockout mice.
• OLAW Online Seminar: Implementing Guidance on Significant Changes: One Institution's Experience - September 8, 2016
• OLAW Online Seminar: Guidance on Significant Changes to Animal Activities - August 21, 2014

SOPs

• FAQ. May standard operating procedures (SOPs) or blanket protocols that cover a number of procedures be utilized in lieu of repeating descriptions of identical procedures in multiple protocols?
• Lab Animal. 2018; 47(5). (PDF - 802 KB) Protocols for pets: what authority does an IACUC have?
• Lab Animal. 2012; 41(8). (PDF - 96 KB) Management of a holding protocol.

Time of grant award

• FAQ. Does the IACUC have to review proposed animal research activities at the time of grant award if the animal research activities will not be conducted until year 4 or 5 of a grant?
• “Just-In-Time”. Federal Register, 8/7/2002, 67 FR 51289 (PDF).
• OLAW Online Seminar: Congruence Review - January 18, 2024

Unapproved work

• FAQ. May the IACUC administratively extend approval of a project that has expired?
• FAQ. May the investigator begin animal work before receiving IACUC approval?
• Lab Animal. 2015; 44(4). (PDF - 650 KB) Congruence between grants and protocols.
• Lab Animal eAlert. 2010; No. 6 (PDF - 334 KB) What is Protocol for Reporting an Animal-Research Project Exceeding Its Expiration Date?